| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
|---|
| Ligand | BDBM214703 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.43±n/a |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 200±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Mereddy, VR; Drewes, LR; Alam, MA; Jonnalagadda, SK; Gurrapu, S Therapeutic compounds US Patent US9296728 Publication Date 3/29/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monocarboxylate transporter 1 |
|---|
| Name: | Monocarboxylate transporter 1 |
|---|
| Synonyms: | MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53245.17 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P53987 |
|---|
| Residue: | 494 |
|---|
| Sequence: | MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSW
ISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIG
GLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLI
LGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQ
TVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAF
VDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAF
GWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACG
VILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPL
QNSSGDPAEEESPV
|
|
|
|---|
| BDBM214703 |
|---|
| n/a |
|---|
| Name | BDBM214703 |
|---|
| Synonyms: | US9296728, 27 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H17F2NO4 |
|---|
| Mol. Mass. | 421.3929 |
|---|
| SMILES | OC(=O)c1cc2ccc(cc2oc1=O)N(Cc1ccc(F)cc1)Cc1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
