| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ghrelin O-acyltransferase |
|---|
| Ligand | BDBM17289 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | GOAT Activity Assay |
|---|
| pH | 7±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | >1.000e+6±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  McGovern-Gooch, KR; Mahajani, NS; Garagozzo, A; Schramm, AJ; Hannah, LG; Sieburg, MA; Chisholm, JD; Hougland, JL Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation. Biochemistry56:919-931 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ghrelin O-acyltransferase |
|---|
| Name: | Ghrelin O-acyltransferase |
|---|
| Synonyms: | GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49733.10 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96T53 |
|---|
| Residue: | 435 |
|---|
| Sequence: | MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYA
VLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITL
SSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSL
CSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFEC
IYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRIS
VFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYL
IHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVY
CILLLLLAKRKHKCN
|
|
|
|---|
| BDBM17289 |
|---|
| n/a |
|---|
| Name | BDBM17289 |
|---|
| Synonyms: | (1S,10R,11S,15S)-5-hydroxy-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-trien-14-one | CHEMBL1405 | Estrone | Estrone (E1) | Estrone, 15 | Estrovarin | Kestrone | Theelin | Unigen | [2,4,6,7-3H]-E1 | [2,4,6,7-3H]-Estrone | folliculin |
|---|
| Type | Steroid |
|---|
| Emp. Form. | C18H22O2 |
|---|
| Mol. Mass. | 270.3661 |
|---|
| SMILES | [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])c3ccc(O)cc3CC[C@@]21[H] |
|---|
| Structure | 
|
|---|
Search and Browse
