| Reaction Details |
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 | Report a problem with these data |
| Target | Ghrelin O-acyltransferase |
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| Ligand | BDBM217390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | GOAT Activity Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 5.00e+5± 1.00e+5 nM |
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| Comments | extracted |
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| Citation |  McGovern-Gooch, KR; Mahajani, NS; Garagozzo, A; Schramm, AJ; Hannah, LG; Sieburg, MA; Chisholm, JD; Hougland, JL Synthetic Triterpenoid Inhibition of Human Ghrelin O-Acyltransferase: The Involvement of a Functionally Required Cysteine Provides Mechanistic Insight into Ghrelin Acylation. Biochemistry56:919-931 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ghrelin O-acyltransferase |
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| Name: | Ghrelin O-acyltransferase |
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| Synonyms: | GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49733.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96T53 |
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| Residue: | 435 |
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| Sequence: | MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYA
VLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITL
SSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSL
CSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFEC
IYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRIS
VFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYL
IHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVY
CILLLLLAKRKHKCN
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| BDBM217390 |
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| n/a |
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| Name | BDBM217390 |
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| Synonyms: | 2-Bromo-2-cyclohexenone, 17 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H7BrO |
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| Mol. Mass. | 175.023 |
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| SMILES | BrC1=CCCCC1=O |t:1| |
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| Structure | 
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