Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 9 subunit alpha | ||
| Ligand | BDBM217696 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Nav1.7 In Vitro PX Assay | ||
| IC50 | 23±n/a nM | ||
| Citation |  Weiss, M; Boezio, A; Boezio, C; Butler, JR; Chu-Moyer, MY; Dimauro, EF; Dineen, T; Graceffa, R; Guzman-Perez, A; Huang, H; Kreiman, C; La, D; Marx, IE; Milgrim, BC; Nguyen, HN; Peterson, E; Romero, K; Sparling, B Bicyclic sulfonamide compounds as sodium channel inhibitors US Patent US9212182 Publication Date 12/15/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 9 subunit alpha | |||
| Name: | Sodium channel protein type 9 subunit alpha | ||
| Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
| Type: | Protein | ||
| Mol. Mass.: | 226375.97 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15858 | ||
| Residue: | 1988 | ||
| Sequence: |
| ||
| BDBM217696 | |||
| n/a | |||
| Name | BDBM217696 | ||
| Synonyms: | US9212182, 672 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H19F3N4O4S | ||
| Mol. Mass. | 552.524 | ||
| SMILES | COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ncccn1)-c1cccc(c1)C(F)(F)F |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;1.33,-6.93,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-2.67,3.08,;-2.67,4.62,;-4,5.39,;-5.33,4.62,;-5.33,3.08,;2.67,-9.24,;1.33,-10.01,;1.33,-11.55,;2.67,-12.32,;4,-11.55,;4,-10.01,;5.33,-12.32,;6.67,-13.09,;4.56,-13.65,;6.1,-10.99,)| | ||
| Structure | 
| ||