Reaction Details |
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Target | S-methyl-5'-thioinosine phosphorylase |
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Ligand | BDBM50246594 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 0.096±n/a nM |
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Comments | extracted |
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Citation | Schramm, VL; Clinch, K; Tyler, PC; Evans, GB; Furneaux, RH Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase US Patent US9290501 Publication Date 3/22/2016 |
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More Info.: | Get all data from this article, Assay Method |
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S-methyl-5'-thioinosine phosphorylase |
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Name: | S-methyl-5'-thioinosine phosphorylase |
Synonyms: | MTIP_PSEAE | S-methyl-5'-thioinosine phosphorylase (MTIP) |
Type: | Enzyme |
Mol. Mass.: | 26266.70 |
Organism: | Pseudomonas aeruginosa |
Description: | Q9HZK1 |
Residue: | 245 |
Sequence: | MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFP
PHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGD
IEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGN
DIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLA
RVLAG
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BDBM50246594 |
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n/a |
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Name | BDBM50246594 |
Synonyms: | (+/-)-7-((1-hydroxy-3-(methylthio)propan-2-ylamino)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL462398 | US9290501, MT-SerMe-ImmH |
Type | Small organic molecule |
Emp. Form. | C11H16N4O2S |
Mol. Mass. | 268.335 |
SMILES | CSCC(CO)NCc1c[nH]c2c1nc[nH]c2=O |
Structure |
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