| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-related protein A1 [1-149] |
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| Ligand | BDBM60828 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DELFIA |
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| IC50 | >1e+3±n/a nM |
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| Citation |  Barile, E; Marconi, GD; De, SK; Baggio, C; Gambini, L; Salem, AF; Kashyap, MK; Castro, JE; Kipps, TJ; Pellecchia, M hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. ACS Chem Biol12:444-455 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-related protein A1 [1-149] |
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| Name: | Bcl-2-related protein A1 [1-149] |
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| Synonyms: | B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl2-related protein A1 (Bfl-1) | GRS | HBPA1 |
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| Type: | Protein |
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| Mol. Mass.: | 19694.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human Bfl-1 truncation (1-149 aa) with N-terminal His-tag. |
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| Residue: | 171 |
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| Sequence: | MHHHHHHSSGVDLGTENLYFQSMTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQ
NVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGI
LIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFE
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| BDBM60828 |
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| n/a |
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| Name | BDBM60828 |
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| Synonyms: | ABT-199 | BDBM189459 | US10213433, Compound 5 | US10377755, Example ABT-199 | US11318134, Example ABT-199 | US11369599, Compound 369 | US11590126, Example ABT-199 | US11718611, Example T-7 | US20240043404, Example 369 | US9174982, 369 |
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| Type | n/a |
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| Emp. Form. | C45H50ClN7O7S |
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| Mol. Mass. | 868.439 |
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| SMILES | CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| |
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| Structure | 
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