Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Ligand | BDBM60828 |
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Substrate/Competitor | n/a |
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Meas. Tech. | DELFIA |
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IC50 | >1e+3±n/a nM |
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Citation | Barile, E; Marconi, GD; De, SK; Baggio, C; Gambini, L; Salem, AF; Kashyap, MK; Castro, JE; Kipps, TJ; Pellecchia, M hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. ACS Chem Biol12:444-455 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
Type: | Membrane; Single-pass membrane protein |
Mol. Mass.: | 37332.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07820 |
Residue: | 350 |
Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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BDBM60828 |
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n/a |
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Name | BDBM60828 |
Synonyms: | ABT-199 | BDBM189459 | US10213433, Compound 5 | US10377755, Example ABT-199 | US11318134, Example ABT-199 | US11369599, Compound 369 | US11590126, Example ABT-199 | US11718611, Example T-7 | US20240043404, Example 369 | US9174982, 369 |
Type | n/a |
Emp. Form. | C45H50ClN7O7S |
Mol. Mass. | 868.439 |
SMILES | CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:57| |
Structure |
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