| Reaction Details |
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 | Report a problem with these data |
| Target | Neurotensin receptor type 1 [45-272,291-390,C386A,C388A] |
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| Ligand | BDBM218811 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SPR Screening Assay |
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| Kd | 1.2e+3± 9e+1 nM |
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| Citation |  Ranganathan, A; Heine, P; Rudling, A; Plückthun, A; Kummer, L; Carlsson, J Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries. ACS Chem Biol12:735-745 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neurotensin receptor type 1 [45-272,291-390,C386A,C388A] |
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| Name: | Neurotensin receptor type 1 [45-272,291-390,C386A,C388A] |
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| Synonyms: | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor type 1 (NTSR1-H4) |
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| Type: | Protein |
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| Mol. Mass.: | 36530.59 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Rat NTSR1 variant (E45-G390 aa with C386A/C388A mutation) lacking intracellular loop 3 (E273-T290) |
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| Residue: | 328 |
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| Sequence: | ESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHY
HLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLS
VERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLV
CTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVHQAAFNMTIEPGRVQA
LRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSS
AINPILYNLVSANFRQVFLSTLAALAPG
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| BDBM218811 |
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| n/a |
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| Name | BDBM218811 |
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| Synonyms: | NTSR-H4 inhibitor, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19ClN2O3 |
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| Mol. Mass. | 298.765 |
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| SMILES | CC(C)C[C@H](NC(=O)NCc1ccccc1Cl)C(O)=O |r| |
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| Structure | 
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