| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase II subunit alpha/beta |
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| Ligand | BDBM218881 |
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| Substrate/Competitor | BDBM220098 |
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| Meas. Tech. | In Vitro Cell-Free Assay |
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| pH | 7.2±n/a |
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| IC50 | <10±n/a nM |
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| Comments | extracted |
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| Citation |  Haddach, M; Tran, JA; Pierre, F; Regan, CF; Raffaele, N; Ravula, S; Ryckman, DM Pyrazolopyrimidines and related heterocycles as CK2 inhibitors US Patent US9303033 Publication Date 4/5/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase II subunit alpha/beta |
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| Name: | Casein kinase II subunit alpha/beta |
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| Synonyms: | Casein kinase 2 (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha alpha beta beta | Complex of catalytic (CK2α) and non-catalytic (CK2β) subunits |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 989485 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Casein kinase II subunit alpha |
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| Synonyms: | CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 45151.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P68400 |
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| Residue: | 391 |
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| Sequence: | MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
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| Component 2 |
| Name: | Casein kinase II subunit beta |
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| Synonyms: | CK II beta | CSK2B_RAT | Casein kinase II beta | Casein kinase II subunit beta | Ck2n | Csnk2b | Phosvitin |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24937.13 |
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| Organism: | Rattus norvegicus |
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| Description: | EBI_10969 |
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| Residue: | 215 |
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| Sequence: | MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
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| BDBM218881 |
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| BDBM220098 |
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| Name | BDBM218881 |
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| Synonyms: | US9303033, M2, Example 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F2N7O2 |
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| Mol. Mass. | 403.386 |
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| SMILES | FC1(F)CCN(CC1)c1cc(NC2CC2)n2ncc(\C=C3/NC(=O)NC3=O)c2n1 |
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| Structure | 
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