| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
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| Ligand | BDBM8891 |
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| Substrate/Competitor | BDBM8582 |
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| Meas. Tech. | Inhibition Assay |
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| Temperature | 310.15±n/a K |
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| IC50 | 2±n/a nM |
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| Comments | extracted |
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| Citation |  Hartmann, R; Voets, M; Müller-Vieira, U Selective inhibitors of human corticosteroid synthases US Patent US9271963 Publication Date 3/1/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B2, mitochondrial |
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| Name: | Cytochrome P450 11B2, mitochondrial |
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| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 57582.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P19099 |
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| Residue: | 503 |
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| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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| BDBM8891 |
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| BDBM8582 |
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| Name | BDBM8891 |
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| Synonyms: | 3-(6-Methoxy-3,4-dihydronaphthalen-2-yl)pyridine | CHEMBL206351 | Dihydronaphthalene 4 | US9271963, 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15NO |
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| Mol. Mass. | 237.2964 |
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| SMILES | COc1ccc2C=C(CCc2c1)c1cccnc1 |c:6| |
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| Structure | 
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