| Reaction Details |
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 | Report a problem with these data |
| Target | Diacylglycerol O-acyltransferase 1 |
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| Ligand | BDBM220397 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | PMSA Inhibition Assay |
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| Ki | 0.024±0.008 nM |
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| IC50 | 0.54±0.18 nM |
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| Citation |  Spiegel, D; Murelli, R; Zhang, A Chimeric small molecules for the recruitment of antibodies to cancer cells US Patent US9296708 Publication Date 3/29/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Diacylglycerol O-acyltransferase 1 |
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| Name: | Diacylglycerol O-acyltransferase 1 |
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| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
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| Type: | Protein |
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| Mol. Mass.: | 55297.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75907 |
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| Residue: | 488 |
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| Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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| BDBM220397 |
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| n/a |
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| Name | BDBM220397 |
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| Synonyms: | US9296708, 3, ARM-P2 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N8O13 |
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| Mol. Mass. | 654.5833 |
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| SMILES | OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCn1cc(COCCOCCNc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)nn1)C(O)=O)C(O)=O |
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| Structure | 
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