Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 2 |
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Ligand | BDBM222081 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Cyclooxygenase (COX) Inhibition Assay |
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IC50 | 7.3e+3±n/a nM |
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Citation | Alsayed, SS; Elshemy, HA; Abdelgawad, MA; Abdel-Latif, MS; Abdellatif, KR Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile. Bioorg Chem70:173-183 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin G/H synthase 2 |
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Name: | Prostaglandin G/H synthase 2 |
Synonyms: | COX2 | Cyclooxygenase-1 (COX-1) | Cyclooxygenase-2 (COX-2) | PGH2_SHEEP | PTGS2 | Prostaglandin G/H synthase (Cyclooxygenase-2) | Prostaglandin G/H synthase (cyclooxygenase) |
Type: | Protein |
Mol. Mass.: | 68976.98 |
Organism: | Ovis aries (Sheep) |
Description: | n/a |
Residue: | 603 |
Sequence: | MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLT
RIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYS
YKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTN
LMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQ
MINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDV
LKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQN
RIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVA
GRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALY
GDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVG
FKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERS
TEL
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BDBM222081 |
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n/a |
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Name | BDBM222081 |
Synonyms: | 4-(4-chlorophenyl)-6-(4-nitrophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (4c) |
Type | Small organic molecule |
Emp. Form. | C18H10ClN3O3 |
Mol. Mass. | 351.743 |
SMILES | [O-][N+](=O)c1ccc(cc1)-c1cc(-c2ccc(Cl)cc2)c(C#N)c(=O)[nH]1 |
Structure |
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