| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 12 |
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| Ligand | BDBM290470 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | hURAT1 Inhibition Assay |
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| IC50 | 11.0±n/a nM |
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| Citation |  Xu, Z; Zhang, N; Sun, Q; Wu, T Condensed ring derivative, and preparation method, intermediate, pharmaceutical composition and use thereof US Patent US10100016 Publication Date 10/16/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 12 |
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| Name: | Solute carrier family 22 member 12 |
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| Synonyms: | OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59638.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96S37 |
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| Residue: | 553 |
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| Sequence: | MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
GTLGNSVLKSTQF
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| BDBM290470 |
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| n/a |
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| Name | BDBM290470 |
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| Synonyms: | US10100016, Compound 43A |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16N2O2S |
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| Mol. Mass. | 372.44 |
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| SMILES | C[C@H](CC(O)=O)c1cc2c(cncc2s1)-c1ccc(C#N)c2ccccc12 |r| |
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| Structure | 
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