| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
|---|
| Ligand | BDBM223578 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.6±n/a |
|---|
| IC50 | 550±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Sugimoto, H; Okuda, M; Nakayama, S; Inoue, Y; Sakata, Y; Fujita, Y; Tokizane, R Pyrazole derivative US Patent US9321752 Publication Date 4/26/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Microtubule-associated protein tau |
|---|
| Name: | Microtubule-associated protein tau |
|---|
| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 78928.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10636 |
|---|
| Residue: | 758 |
|---|
| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
|
|
|
|---|
| BDBM223578 |
|---|
| n/a |
|---|
| Name | BDBM223578 |
|---|
| Synonyms: | US9321752, 20-3 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22N4O |
|---|
| Mol. Mass. | 382.4577 |
|---|
| SMILES | Cn1cccc1\C=C\c1cc(\C=C\c2ccc(OCc3ccccn3)cc2)n[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
