| Reaction Details |
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 | Report a problem with these data |
| Target | DNA helicase [35-727] |
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| Ligand | BDBM50055660 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | DNA Helicase Assay |
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| pH | 8±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 4.7e+3±n/a nM |
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| Citation |  Tarique, M; Tabassum, F; Ahmad, M; Tuteja, R Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth. BMC Biochem15:9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA helicase [35-727] |
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| Name: | DNA helicase [35-727] |
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| Synonyms: | UvrD helicase (PfUDN) |
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| Type: | Enzyme |
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| Mol. Mass.: | 81959.48 |
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| Organism: | Plasmodium falciparum |
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| Description: | N-terminal fragment of P. falciparum UvrD helicase (35-727 aa) |
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| Residue: | 693 |
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| Sequence: | NFSEEQQRIIEIPMNVNLCIIACPGSGKTSTLTARIIKSIIEEKQSIVCITFTNYAASDL
KDKIMKKINCLIDICVDNKINQKLFNNKNNKINFSLKNKCTLNNKMNKSIFKVLNTVMFI
GTIHSFCRYILYKYKGTFKILTDFINTNIIKLAFNNFYSSMMSKTKGTQPGFSTILERKS
NKASTQNCDPDKINTHNNDDNINNKNDYINNKNKNDYNNINNYDNINNYDNINNDDNINN
DDNINNDDNINNDDNINNDDDINNCGNCNQPKGIPSQLAYFINCMKNAEIKEDEEKEFYE
EEHDIQNDILNNDDNNNDEDDDDDDEFYNYLYNFKHSYEQTNDYFANEQVQSVLKKKNII
FLKKKIKLMKYIELYNIKIEINDVEKMFYEEYKKIFKKAKNIYYDFDDLLIETYRLMKDN
ADIRNKILEEWNYVFCDEFQDTNTTQFNILQFFVNHNVPSTLDQSIYTSGNLENKDIKDN
HNISMSTYKSKQYSHSVQNFFNEHKVDQQLCDQIYFDKHCNNILMQNKNQQATHKHSEEE
EEQEEEKKKNKKTKKTNTFINQQKIKTQTVLSYKQDEMSSSASSTYSYVKIEKEKKKYAL
NKIDDTYYNKKNIYSNNDEILDIENEQTFFNNNCNEKNKTKKKCNLKDRSLTVIGDDDQS
IYSFRGAHINVFYKFLKDCNCLLFKLNNNFRST
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| BDBM50055660 |
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| n/a |
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| Name | BDBM50055660 |
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| Synonyms: | 1-amino-3-(4-(4-(2-(amino(iminio)methylamino)acetamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamido)propan-1-iminium | 2N-(3-amino-3-iminopropyl)-4-[4-amino(imino)methylaminomethylcarboxamido-1-methyl-1H-2-pyrrolylcarboxamido]-1-methyl-1H-2-pyrrolecarboxamide | 2N-(3-amino-3-iminopropyl)-4-[4-amino(imino)methylaminomethylcarboxamido-1-methyl-1H-2-pyrrolylcarboxamido]-1-methyl-1H-2-pyrrolecarboxamide(netropsin) | 4-(2-Guanidino-acetylamino)-1-methyl-1H-pyrrole-2-carboxylic acid [5-(2-carbamimidoyl-ethylcarbamoyl)-1-methyl-2,3-dihydro-1H-pyrrol-3-yl]-amide | CHEMBL307767 | NETROPSIN |
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| Type | Small organic molecule |
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| Emp. Form. | C18H26N10O3 |
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| Mol. Mass. | 430.4642 |
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| SMILES | [#6]-n1cc(-[#7]-[#6](=O)-c2cc(-[#7]-[#6](=O)-[#6]\[#7]=[#6](\[#7])-[#7])cn2-[#6])cc1-[#6](=O)-[#7]-[#6]-[#6]-[#6](-[#7])=[#7] |
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| Structure | 
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