Ki Summary

Reaction Details

Report a problem with these data

Target

DNA helicase [35-727]

Ligand

BDBM50370548

Substrate/Competitor

n/a

Meas. Tech.

DNA Helicase Assay

8±0

Temperature

310.15±0 K

IC50

3.5e+3±n/a nM

Citation

Tarique, M; Tabassum, F; Ahmad, M; Tuteja, R Plasmodium falciparum UvrD activities are downregulated by DNA-interacting compounds and its dsRNA inhibits malaria parasite growth. BMC Biochem15:9 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

DNA helicase [35-727]

Name:

DNA helicase [35-727]

Synonyms:

UvrD helicase (PfUDN)

Type:

Enzyme

Mol. Mass.:

81959.48

Organism:

Plasmodium falciparum

Description:

N-terminal fragment of P. falciparum UvrD helicase (35-727 aa)

Residue:

693

Sequence:

NFSEEQQRIIEIPMNVNLCIIACPGSGKTSTLTARIIKSIIEEKQSIVCITFTNYAASDL
KDKIMKKINCLIDICVDNKINQKLFNNKNNKINFSLKNKCTLNNKMNKSIFKVLNTVMFI
GTIHSFCRYILYKYKGTFKILTDFINTNIIKLAFNNFYSSMMSKTKGTQPGFSTILERKS
NKASTQNCDPDKINTHNNDDNINNKNDYINNKNKNDYNNINNYDNINNYDNINNDDNINN
DDNINNDDNINNDDNINNDDDINNCGNCNQPKGIPSQLAYFINCMKNAEIKEDEEKEFYE
EEHDIQNDILNNDDNNNDEDDDDDDEFYNYLYNFKHSYEQTNDYFANEQVQSVLKKKNII
FLKKKIKLMKYIELYNIKIEINDVEKMFYEEYKKIFKKAKNIYYDFDDLLIETYRLMKDN
ADIRNKILEEWNYVFCDEFQDTNTTQFNILQFFVNHNVPSTLDQSIYTSGNLENKDIKDN
HNISMSTYKSKQYSHSVQNFFNEHKVDQQLCDQIYFDKHCNNILMQNKNQQATHKHSEEE
EEQEEEKKKNKKTKKTNTFINQQKIKTQTVLSYKQDEMSSSASSTYSYVKIEKEKKKYAL
NKIDDTYYNKKNIYSNNDEILDIENEQTFFNNNCNEKNKTKKKCNLKDRSLTVIGDDDQS
IYSFRGAHINVFYKFLKDCNCLLFKLNNNFRST

BDBM50370548

n/a

Name

BDBM50370548

Synonyms:

NOGALAMYCIN

Type

Small organic molecule

Emp. Form.

C39H49NO16

Mol. Mass.

787.8035

SMILES

CO[C@H]1[C@H](C)O[C@@H](O[C@H]2C[C@](C)(O)[C@H](C(=O)OC)c3cc4C(=O)c5c6O[C@@H]7O[C@@](C)([C@H](O)[C@H]([C@@H]7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)[C@H](OC)[C@]1(C)OC |r|

Structure