| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 2 [258-605] |
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| Ligand | BDBM223974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Di-UB K63-2 Hydrolysis Assay |
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| IC50 | >1.00e+5±n/a nM |
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| Citation |  Magiera, K; Tomala, M; Kubica, K; De Cesare, V; Trost, M; Zieba, BJ; Kachamakova-Trojanowska, N; Les, M; Dubin, G; Holak, TA; Skalniak, L Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol24:458-470 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 2 [258-605] |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 2 [258-605] |
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| Synonyms: | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin-specific peptidase 2a (USP2a) |
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| Type: | Enzyme |
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| Mol. Mass.: | 40094.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Hman USP2a (258-605 aa) |
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| Residue: | 348 |
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| Sequence: | MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEE
FAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVT
LRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDP
FWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKI
LVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGH
YTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
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| BDBM223974 |
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| n/a |
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| Name | BDBM223974 |
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| Synonyms: | LCAMR |
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| Type | Small organic molecule |
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| Emp. Form. | C28H47NO3 |
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| Mol. Mass. | 445.6777 |
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| SMILES | C[C@H](CCC(=O)N1CCOCC1)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r| |
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| Structure | 
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