| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 2B6 |
|---|
| Ligand | BDBM224811 |
|---|
| Substrate/Competitor | US9333197, Bupropion |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| IC50 | 19200±n/a nM |
|---|
| Citation |  Notte, G Apoptosis signal-regulating kinase inhibitor US Patent US9333197 Publication Date 5/10/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 2B6 |
|---|
| Name: | Cytochrome P450 2B6 |
|---|
| Synonyms: | CP2B6_HUMAN | CYP2B6 | Cytochrome P450 2B6 (CYP2B6) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 56289.75 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P20813 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC
SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE
INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
PPTYQIRFLPR
|
|
|
|---|
| BDBM224811 |
|---|
| US9333197, Bupropion |
|---|
| Name | BDBM224811 |
|---|
| Synonyms: | US9333197, Hydroxybupropion |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H18ClNO2 |
|---|
| Mol. Mass. | 255.741 |
|---|
| SMILES | CC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
