Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase Chk1 [2-280]

Ligand

BDBM225338

Substrate/Competitor

n/a

Meas. Tech.

33P-Radiometric_Method1

19.9±n/a nM

Citation

D3R, DD Abbott CHK1 Kinase D3R D3R Publication Date 6/30/2015

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase Chk1 [2-280]

Name:

Serine/threonine-protein kinase Chk1 [2-280]

Synonyms:

CHEK1 | CHK1 | CHK1_HUMAN | CHK1_Kinase

Type:

n/a

Mol. Mass.:

32109.16

Organism:

Homo sapiens (Human)

Description:

O14757[2-280]

Residue:

279

Sequence:

AVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKM
LNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYL
HGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKR
REFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLAL
LHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTS

BDBM225338

n/a

Name

BDBM225338

Synonyms:

Chk1_20

Type

Small Organic Molecule

Emp. Form.

C25H27N3O2

Mol. Mass.

401.5008

SMILES

CC1CCC(CC1)NCc1ccc-2c(Cc3c-2n[nH]c3-c2ccc(cc2)C(O)=O)c1 |(-8.72,1.74,;-7.22,1.4,;-6.17,2.52,;-4.67,2.17,;-4.22,.7,;-5.27,-.43,;-6.77,-.08,;-2.72,.35,;-1.67,1.47,;-.17,1.12,;.28,-.35,;1.78,-.7,;2.83,.42,;2.39,1.89,;3.65,2.77,;4.88,1.84,;4.37,.39,;5.6,-.54,;6.86,.34,;6.42,1.81,;7.35,3.04,;6.75,4.46,;7.68,5.69,;9.21,5.5,;9.8,4.08,;8.88,2.85,;10.14,6.73,;9.54,8.14,;11.66,6.53,;.89,2.24,)|

Structure