Ki Summary

Reaction Details

Report a problem with these data

Target

Genome polyprotein [1027-1711]

Ligand

BDBM229539

Substrate/Competitor

n/a

Meas. Tech.

Reporter Assay

Temperature

310.15±n/a K

EC50

20±15 nM

Comments

extracted

Citation

Gillis, EP; Bowsher, MS; Scola, PM Hepatitis C virus inhibitors US Patent US9334279 Publication Date 5/10/2016

More Info.:

Get all data from this article, Assay Method

Genome polyprotein [1027-1711]

Name:

Genome polyprotein [1027-1711]

Synonyms:

NS3-NS4A Protease | NS3/4A protease | POLG_HCV77

Type:

n/a

Mol. Mass.:

72913.15

Organism:

Hepatitis C virus genotype 1a (strain H77) (HCV)

Description:

amino acids 1027 to 1711

Residue:

685

Sequence:

APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAG
TRTIASPKGPVIQTYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR
SPVFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAKGYKVLVLNPSVAATLGFGA
YMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADAGCSGGAYDIIICDECHSTDATSI
SGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIK
GGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLGFWEGVFTGLT
HIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMRKCLIRLKPTLHGPTPLLY
RLGAVQNEVTLTHPITKYIMTCMSADLEVVTSTWVLVGGVLAALAAYCLSTGCVVIVGRI
VLSGKPAIIPDREVLYQEFDEMEEC

BDBM229539

n/a

Name

BDBM229539

Synonyms:

US9334279, 1015

Type

Small organic molecule

Emp. Form.

C38H49F3N6O8S2

Mol. Mass.

838.956

SMILES

C[C@@H]1CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C1)Oc1cc(C)nc(c1)-c1cncs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:4|

Structure