| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1028-1200,1251-1711] |
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| Ligand | BDBM229544 |
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| Substrate/Competitor | n/a |
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| EC50 | 3±2 nM |
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| Citation |  Gillis, EP; Bowsher, MS; Scola, PM Hepatitis C virus inhibitors US Patent US9334279 Publication Date 5/10/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1028-1200,1251-1711] |
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| Name: | Genome polyprotein [1028-1200,1251-1711] |
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| Synonyms: | NS3/4A protease | POLG_HCVJ4 |
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| Type: | n/a |
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| Mol. Mass.: | 67564.11 |
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| Organism: | Hepatitis C virus genotype 1b (strain J4L2S) (HCV) |
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| Description: | amino acids 1027 to 1711 |
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| Residue: | 634 |
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| Sequence: | PITAYSQQTRGVLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCINGVCWTVYHGAGS
KTLAGPKGPITQMYTNVDLDLVGWQAPPGARSMTPCSCGSSDLYLVTRHADVIPVRRRGD
SRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGVFRAAVCTRGVAKAVDFIPVESVLVLNPS
VAATLGFGAYMSKAHGIDPNIRTGVRTITTGGSITYSTYGKFLADGGCSGGAYDIIICDE
CHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEIGLSNNGEIPFYG
KAIPIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPPIGDVVVVAT
DALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRSG
IYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEF
WESVFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPT
LHGPTPLLYRLGAVQNEVILTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTT
GSVVIVGRIILSGKPAVVPDREVLYQEFDEMEEC
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| BDBM229544 |
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| n/a |
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| Name | BDBM229544 |
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| Synonyms: | US9334279, 1020 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H58F3N7O9S |
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| Mol. Mass. | 954.065 |
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| SMILES | CC(C)Oc1ccc(cc1)-c1cc(O[C@@H]2C[C@@H]3N(C2)C(=O)[C@@H](NC(=O)OC(C)(C)C(F)(F)F)[C@H](C)C[C@@H](C)CC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2(C)CC2)cc(n1)-c1ncccn1 |r,c:42| |
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| Structure | 
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