| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1028-1200,1251-1711] |
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| Ligand | BDBM229558 |
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| Substrate/Competitor | n/a |
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| EC50 | 0.75±0.25 nM |
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| Citation |  Gillis, EP; Bowsher, MS; Scola, PM Hepatitis C virus inhibitors US Patent US9334279 Publication Date 5/10/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1028-1200,1251-1711] |
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| Name: | Genome polyprotein [1028-1200,1251-1711] |
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| Synonyms: | NS3/4A protease | POLG_HCVJ4 |
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| Type: | n/a |
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| Mol. Mass.: | 67564.11 |
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| Organism: | Hepatitis C virus genotype 1b (strain J4L2S) (HCV) |
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| Description: | amino acids 1027 to 1711 |
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| Residue: | 634 |
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| Sequence: | PITAYSQQTRGVLGCIITSLTGRDKNQVEGEVQVVSTATQSFLATCINGVCWTVYHGAGS
KTLAGPKGPITQMYTNVDLDLVGWQAPPGARSMTPCSCGSSDLYLVTRHADVIPVRRRGD
SRGSLLSPRPVSYLKGSSGGPLLCPSGHVVGVFRAAVCTRGVAKAVDFIPVESVLVLNPS
VAATLGFGAYMSKAHGIDPNIRTGVRTITTGGSITYSTYGKFLADGGCSGGAYDIIICDE
CHSTDSTTILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIEEIGLSNNGEIPFYG
KAIPIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPPIGDVVVVAT
DALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTVPQDAVSRSQRRGRTGRGRSG
IYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEF
WESVFTGLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPT
LHGPTPLLYRLGAVQNEVILTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTT
GSVVIVGRIILSGKPAVVPDREVLYQEFDEMEEC
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| BDBM229558 |
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| n/a |
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| Name | BDBM229558 |
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| Synonyms: | US9334279, 1034 |
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| Type | Small organic molecule |
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| Emp. Form. | C48H59F3N6O11S2 |
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| Mol. Mass. | 1017.141 |
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| SMILES | CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1cncs1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:8| |
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| Structure | 
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