| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [1027-1711] |
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| Ligand | BDBM229561 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Reporter Assay |
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| Temperature | 310.15±n/a K |
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| EC50 | 3±2 nM |
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| Comments | extracted |
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| Citation |  Gillis, EP; Bowsher, MS; Scola, PM Hepatitis C virus inhibitors US Patent US9334279 Publication Date 5/10/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Genome polyprotein [1027-1711] |
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| Name: | Genome polyprotein [1027-1711] |
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| Synonyms: | NS3-NS4A Protease | NS3/4A protease | POLG_HCV77 |
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| Type: | n/a |
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| Mol. Mass.: | 72913.15 |
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| Organism: | Hepatitis C virus genotype 1a (strain H77) (HCV) |
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| Description: | amino acids 1027 to 1711 |
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| Residue: | 685 |
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| Sequence: | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAG
TRTIASPKGPVIQTYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR
SPVFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAKGYKVLVLNPSVAATLGFGA
YMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADAGCSGGAYDIIICDECHSTDATSI
SGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIK
GGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLGFWEGVFTGLT
HIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMRKCLIRLKPTLHGPTPLLY
RLGAVQNEVTLTHPITKYIMTCMSADLEVVTSTWVLVGGVLAALAAYCLSTGCVVIVGRI
VLSGKPAIIPDREVLYQEFDEMEEC
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| BDBM229561 |
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| n/a |
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| Name | BDBM229561 |
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| Synonyms: | US9334279, 1037 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H61F3N6O11S |
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| Mol. Mass. | 1011.113 |
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| SMILES | CC[C@@H]1O[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)OC1(CCCOC1)C(F)(F)F)Oc1cc(nc(c1)-c1ccccn1)-c1ccc(OC(C)C)cc1)C(=O)NS(=O)(=O)C1(C)CC1 |r,c:8| |
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| Structure | 
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