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TargetGenome polyprotein [1027-1711]
LigandBDBM229581
Substrate/Competitorn/a
Meas. Tech.Reporter Assay
Temperature310.15±n/a K
EC50 3±2 nM
Commentsextracted
Citation Gillis, EPBowsher, MSScola, PM Hepatitis C virus inhibitors US Patent US9334279 Publication Date 5/10/2016
More Info.:Get all data from this article,  Assay Method
 
Genome polyprotein [1027-1711]
Name:Genome polyprotein [1027-1711]
Synonyms:NS3-NS4A Protease | NS3/4A protease | POLG_HCV77
Type:n/a
Mol. Mass.:72913.15
Organism:Hepatitis C virus genotype 1a (strain H77) (HCV)
Description:amino acids 1027 to 1711
Residue:685
Sequence:
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAG
TRTIASPKGPVIQTYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRG
DSRGSLLSPRPISYLKGSSGGPLLCPTGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMR
SPVFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAKGYKVLVLNPSVAATLGFGA
YMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADAGCSGGAYDIIICDECHSTDATSI
SGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIK
GGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTG
DFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGE
RPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLGFWEGVFTGLT
HIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMRKCLIRLKPTLHGPTPLLY
RLGAVQNEVTLTHPITKYIMTCMSADLEVVTSTWVLVGGVLAALAAYCLSTGCVVIVGRI
VLSGKPAIIPDREVLYQEFDEMEEC
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  Blast E-value cutoff:
BDBM229581
n/a
NameBDBM229581
Synonyms:US9334279, 1057
TypeSmall organic molecule
Emp. Form.C48H60N6O9S2
Mol. Mass.929.155
SMILESCC[C@@H]1C[C@H](C)CC\C=C/[C@@H]2C[C@]2(NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H]1NC(=O)O[C@@H]1C[C@@H]2C[C@@H]2C1)Oc1cc(nc(c1)-c1ccc(OC(C)C)cc1)-c1nccs1)C(=O)NS(=O)(=O)C1CC1 |r,c:8|
Structure
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