| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM163642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cell-Based Assay |
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| IC50 | 1688.9±24.12 nM |
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| Citation |  Redinbo, MR Selective β-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents US Patent US9334288 Publication Date 5/10/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase) |
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| Type: | Protein |
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| Mol. Mass.: | 74736.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 651 |
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| Sequence: | MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
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| BDBM163642 |
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| n/a |
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| Name | BDBM163642 |
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| Synonyms: | Methyl 2amino5[(3chloro4methylphenyl)carbamoyl]4methylthiophene3carboxylate (Inh 7) | US9334288, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN2O3S |
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| Mol. Mass. | 338.809 |
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| SMILES | COC(=O)c1c(N)sc(C(=O)Nc2ccc(C)c(Cl)c2)c1C |
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| Structure | 
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