| Reaction Details |
|---|
 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP [241-356] |
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| Ligand | BDBM228596 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | >54.8±n/a nM |
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| Comments | extracted |
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| Citation |  Hogg, JH; Lou, Y Azaindolines US Patent US9340573 Publication Date 5/17/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| E3 ubiquitin-protein ligase XIAP [241-356] |
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| Name: | E3 ubiquitin-protein ligase XIAP [241-356] |
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| Synonyms: | API3 | BIRC4 | Baculoviral IAP repeat (BIR) domains BIR3 | IAP3 | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 14528.99 |
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| Organism: | Artificial Sequence |
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| Description: | 6x Histidine-tagged BIR3 domain (241-356 aa of XIAP) |
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| Residue: | 125 |
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| Sequence: | MRHHHHHHRSDAVSSDRNFPNSTNLPRNPSMADYEARIFTEGTWIYSVNKEQLARAGFYA
LGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEEC
LVRTT
|
|
|
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| BDBM228596 |
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| n/a |
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| Name | BDBM228596 |
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| Synonyms: | US9340573, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32N6O3 |
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| Mol. Mass. | 452.5493 |
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| SMILES | CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@H](CNC(=O)Nc2ccccc2)Cc2cccnc12 |
|---|
| Structure | 
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