| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM232306 |
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| Substrate/Competitor | US9346794, MeOSuc-Ala-Ala-Pro-Val-AMC |
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| Meas. Tech. | Human Neutrophil Elastase Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.2±n/a nM |
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| Comments | extracted |
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| Citation |  Oost, T; Fiegen, D; Gnamm, C Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity US Patent US9346794 Publication Date 5/24/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM232306 |
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| US9346794, MeOSuc-Ala-Ala-Pro-Val-AMC |
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| Name | BDBM232306 |
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| Synonyms: | US9346794, 10 | US9346794, 10A | US9346794, 10B |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25F3N4O3S |
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| Mol. Mass. | 530.562 |
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| SMILES | CCn1cc(C(=O)NCc2ccc(cc2)S(=O)(CC)=NC#N)c(=O)c(c1C)-c1cccc(c1)C(F)(F)F |
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| Structure | 
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