Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM232316 |
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Substrate/Competitor | US9346794, MeOSuc-Ala-Ala-Pro-Val-AMC |
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Meas. Tech. | Human Neutrophil Elastase Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 5.6±n/a nM |
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Comments | extracted |
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Citation | Oost, T; Fiegen, D; Gnamm, C Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity US Patent US9346794 Publication Date 5/24/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM232316 |
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US9346794, MeOSuc-Ala-Ala-Pro-Val-AMC |
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Name | BDBM232316 |
Synonyms: | US9346794, 20 |
Type | Small organic molecule |
Emp. Form. | C26H23F3N4O3S |
Mol. Mass. | 528.546 |
SMILES | Cc1c(-c2cccc(c2)C(F)(F)F)c(=O)c(cn1C1CC1)C(=O)NCc1ccc(cc1)S(C)(=O)=NC#N |
Structure |
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