| Reaction Details |
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 | Report a problem with these data |
| Target | Ras-like protein 2 |
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| Ligand | BDBM233129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence-Based PFTase Inhibition Assay |
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| pH | 7.5±0 |
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| Temperature | 303.15±0 K |
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| IC50 | 6.6e+4±n/a nM |
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| Citation |  Pinel, B; Dubois, J; Séraphin, D; Richomme, P Semisynthesis of alpha-methyl-gamma-lactones and in vitro evaluation of their activity on protein farnesyltransferase. J Enzyme Inhib Med Chem25:172-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ras-like protein 2 |
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| Name: | Ras-like protein 2 |
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| Synonyms: | ASC1 | CTN5 | GLC5 | Protein farnesyltransferase (PFTase) | RAS2 | RAS2_YEAST |
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| Type: | Enzyme |
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| Mol. Mass.: | 34705.81 |
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| Organism: | Saccharomyces cerevisiae (Baker's yeast) |
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| Description: | P01120 |
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| Residue: | 322 |
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| Sequence: | MPLNKSNIREYKLVVVGGGGVGKSALTIQLTQSHFVDEYDPTIEDSYRKQVVIDDEVSIL
DILDTAGQEEYSAMREQYMRNGEGFLLVYSITSKSSLDELMTYYQQILRVKDTDYVPIVV
VGNKSDLENEKQVSYQDGLNMAKQMNAPFLETSAKQAINVEEAFYTLARLVRDEGGKYNK
TLTENDNSKQTSQDTKGSGANSVPRNSGGHRKMSNAANGKNVNSSTTVVNARNASIESKT
GLAGNQATNGKTQTDRTNIDNSTGQAGQANAQSANTVNNRVNNNSKAGQVSNAKQARKQQ
AAPGGNTSEASKSGSGGCCIIS
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| BDBM233129 |
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| n/a |
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| Name | BDBM233129 |
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| Synonyms: | 11β,13-Dihydroxanthatin-1,5β-epoxide (12) |
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| Type | Small organic molecule |
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| Emp. Form. | C15H20O4 |
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| Mol. Mass. | 264.3169 |
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| SMILES | C[C@@H]1[C@H]2C[C@@H]3O[C@]3(\C=C\C(C)=O)[C@@H](C)C[C@@H]2OC1=O |r| |
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| Structure | 
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