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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase pim-1 | ||
| Ligand | BDBM161970 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | PIM-1 Biochemical Assay | ||
| IC50 | <100±n/a nM | ||
| Citation |  Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase pim-1 | |||
| Name: | Serine/threonine-protein kinase pim-1 | ||
| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 35681.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11309 | ||
| Residue: | 313 | ||
| Sequence: |
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| BDBM161970 | |||
| n/a | |||
| Name | BDBM161970 | ||
| Synonyms: | US9682991, 19 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H23F3N6O3 | ||
| Mol. Mass. | 464.4409 | ||
| SMILES | CN1CCOc2c1c(N[C@H]1CC[C@H](O)CC1)nn1c(nnc21)-c1cccc(OC(F)(F)F)c1 |r,wU:12.13,wD:9.9,(-4.94,3.47,;-3.61,4.24,;-3.61,5.78,;-2.27,6.55,;-.94,5.78,;-.94,4.24,;-2.27,3.47,;-2.27,1.93,;-3.61,1.16,;-3.61,-.38,;-4.94,-1.15,;-4.94,-2.69,;-3.61,-3.46,;-3.61,-5,;-2.27,-2.69,;-2.27,-1.15,;-.94,1.16,;.39,1.93,;1.86,1.45,;2.76,2.7,;1.86,3.94,;.39,3.47,;2.63,.12,;4.17,.12,;4.94,-1.21,;4.17,-2.55,;2.63,-2.55,;1.86,-3.88,;2.63,-5.22,;3.4,-6.55,;4.17,-5.22,;1.86,-6.55,;1.86,-1.21,)| | ||
| Structure | 
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