Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase pim-2

Ligand

BDBM161986

Substrate/Competitor

n/a

Meas. Tech.

PIM-2 Biochemical Assay

IC50

<100±n/a nM

Citation

Pastor Fernández, J; Ramos Lima, FJ; Hernandez Higueras, AI; Martínez González, S; Martín Hernando, JI; Saluste, CP; Gonzalez Cantalapiedra, E; Blanco Aparicio, C; Rodríguez Hergueta, A; Garcia Collazo, AM; Salgado Serrano, A; Noya Marino, B Tricyclic compounds for use as kinase inhibitors US Patent US9682991 Publication Date 6/20/2017

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-2

Name:

Serine/threonine-protein kinase pim-2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

34185.93

Organism:

Homo sapiens (Human)

Description:

Q9P1W9

Residue:

311

Sequence:

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP

BDBM161986

n/a

Name

BDBM161986

Synonyms:

US9682991, 35

Type

Small organic molecule

Emp. Form.

C22H25F3N6O3

Mol. Mass.

478.4675

SMILES

CN([C@H]1CC[C@H](O)CC1)c1nn2c(nnc2c2OCCN(C)c12)-c1cccc(OC(F)(F)F)c1 |r,wU:2.1,wD:5.5,(-6.57,1.15,;-5.24,.38,;-5.24,-1.16,;-3.91,-1.93,;-3.91,-3.47,;-5.24,-4.23,;-5.24,-5.77,;-6.57,-3.47,;-6.57,-1.93,;-3.91,1.15,;-2.57,.39,;-1.24,1.15,;.23,.68,;1.13,1.92,;.23,3.17,;-1.24,2.69,;-2.57,3.46,;-2.57,5,;-3.91,5.77,;-5.24,5,;-5.24,3.46,;-6.57,2.69,;-3.91,2.69,;.62,-.81,;-.46,-1.9,;-.07,-3.38,;1.42,-3.78,;2.51,-2.69,;4,-3.09,;5.09,-2,;6.57,-2.4,;4.69,-.52,;5.49,-3.49,;2.11,-1.21,)|

Structure