| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor gamma |
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| Ligand | BDBM50030474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pharmacological In Vitro Assay |
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| pH | 8.2±n/a |
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| Temperature | 277.15±n/a K |
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| Ki | 8±0.0 nM |
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| Comments | extracted |
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| Citation |  Liutkus, M; Caijo, F; Girard, AL; Ayral, E; Audinot, V; Boutin, JA; Renard, P; Caignard, DH; Dacquet, C; Ktorza, A; Mosset, P; Grée, R Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors. J Enzyme Inhib Med Chem25:653-72 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor gamma |
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| Name: | Peroxisome proliferator-activated receptor gamma |
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| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARγ) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 |
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| Type: | Nuclear Receptor |
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| Mol. Mass.: | 57613.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37231 |
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| Residue: | 505 |
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| Sequence: | MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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| BDBM50030474 |
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| n/a |
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| Name | BDBM50030474 |
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| Synonyms: | Avandamet | Avandaryl | Avandia | BRL-49653 | CHEBI:50122 | Rosiglitazone | US10744117, Compound Rosiglitazone | US9562012, rosiglitazone |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N3O3S |
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| Mol. Mass. | 357.427 |
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| SMILES | CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 |
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| Structure | 
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