Reaction Details |
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Target | Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
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Ligand | BDBM234836 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence Polarization Assay |
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Ki | 0.004±n/a nM |
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Citation | Kuduk, SD; McComas, CC; Reger, TS; Qi, C Substituted pyridizinone derivatives as PDE10 inhibitors US Patent US9353104 Publication Date 5/31/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
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Name: | Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
Synonyms: | PDE10A | PDE10_HUMAN | Phosphodiesterase 10A | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase 10A2 | Phosphodiesterase 10A2 (PDE10A) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2) |
Type: | Enzyme |
Mol. Mass.: | 89387.03 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y233-2 |
Residue: | 789 |
Sequence: | MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD
GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG
PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV
AQKAAASED
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BDBM234836 |
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n/a |
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Name | BDBM234836 |
Synonyms: | US9353104, 141 |
Type | Small organic molecule |
Emp. Form. | C19H21ClN6O3S |
Mol. Mass. | 448.926 |
SMILES | COc1ccc(nc1)[C@H]1C[C@@H]1COc1nn(C)c(=O)c(NCc2nnc(C)s2)c1Cl |r| |
Structure |
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