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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tumor necrosis factor | ||
| Ligand | BDBM235369 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ELISA Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 20±n/a nM | ||
| Comments | extracted | ||
| Citation |  Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tumor necrosis factor | |||
| Name: | Tumor necrosis factor | ||
| Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 25645.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P01375 | ||
| Residue: | 233 | ||
| Sequence: |
| ||
| BDBM235369 | |||
| n/a | |||
| Name | BDBM235369 | ||
| Synonyms: | US10085990, Example 99 | US9393245, 99 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H24ClN3O3 | ||
| Mol. Mass. | 449.929 | ||
| SMILES | COc1cccc2c1ncc1c2n(C2CCC(C)CC2)c(=O)n(-c2ccccc2Cl)c1=O |(-4.67,-5,;-3.33,-4.23,;-3.33,-2.69,;-4.67,-1.93,;-4.67,-.38,;-3.33,.38,;-2,-.38,;-2,-1.93,;-.67,-2.69,;.67,-1.93,;.67,-.38,;-.67,.38,;-.67,1.93,;-2,2.69,;-2,4.23,;-3.33,5,;-4.67,4.23,;-6,5,;-4.67,2.69,;-3.33,1.93,;.67,2.69,;.67,4.23,;2,1.93,;3.33,2.69,;3.33,4.23,;4.67,5,;6,4.23,;6,2.69,;4.67,1.93,;4.67,.38,;2,.38,;3.33,-.38,)| | ||
| Structure | 
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