Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM235375 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ELISA Assay |
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Temperature | 298.15±n/a K |
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IC50 | 1±n/a nM |
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Comments | extracted |
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Citation | Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM235375 |
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n/a |
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Name | BDBM235375 |
Synonyms: | US10085990, Example 107 | US9393245, 107 |
Type | Small organic molecule |
Emp. Form. | C29H30N4O7 |
Mol. Mass. | 546.5711 |
SMILES | COc1cccc2c1ncc1c2n(C2CCN(CC2)C(=O)OC(C)(C)C)c(=O)n(-c2ccc3OCOc3c2)c1=O |
Structure |
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