Reaction Details |
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Target | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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Ligand | BDBM135812 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TR-FRET-Based Assay |
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Temperature | 303.15±n/a K |
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IC50 | 17000±n/a nM |
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Comments | extracted |
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Citation | Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
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Name: | Isoform PDE4B2 of cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) |
Synonyms: | DPDE4 | PDE4B | PDE4B2 | PDE4B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B2) | phosphodiesterase 4B2 |
Type: | Enzyme |
Mol. Mass.: | 64320.36 |
Organism: | Homo sapiens (Human) |
Description: | Q07343-2 |
Residue: | 564 |
Sequence: | MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQKLAMETLEELDWCLDQ
LETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPT
QKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNI
FNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAA
DVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTM
VETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDK
ERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY
QSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVID
PENRDSLGETDIDIATEDKSPVDT
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BDBM135812 |
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n/a |
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Name | BDBM135812 |
Synonyms: | US10085990, Example 30 | US10568888, Example 30 | US8853226, 30 | US9393245, 30 | US9833457, 30 |
Type | Small organic molecule |
Emp. Form. | C18H18ClN3O2 |
Mol. Mass. | 343.807 |
SMILES | CCn1c(=O)n(C2CCCC2)c2c3cccc(Cl)c3ncc2c1=O |
Structure |
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