Reaction Details |
| Report a problem with these data |
Target | Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) |
---|
Ligand | BDBM135815 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | TR-FRET-Based Assay |
---|
Temperature | 303.15±n/a K |
---|
IC50 | 616±n/a nM |
---|
Comments | extracted |
---|
Citation | Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) |
---|
Name: | Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) |
Synonyms: | DPDE3 | PDE4D | PDE4D_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) | phosphodiesterase 4D |
Type: | Enzyme |
Mol. Mass.: | 68570.22 |
Organism: | Homo sapiens (Human) |
Description: | Q08499-3 |
Residue: | 604 |
Sequence: | MSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINK
ATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRS
GNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFG
VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLI
TYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVD
HPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKM
VIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPT
KPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWET
WADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGE
SDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDR
SPDT
|
|
|
BDBM135815 |
---|
n/a |
---|
Name | BDBM135815 |
Synonyms: | US10085990, Example 51 | US10568888, Example 51 | US8853226, 51 | US9393245, 51 | US9833457, 51 |
Type | Small organic molecule |
Emp. Form. | C22H21N3O3S |
Mol. Mass. | 407.485 |
SMILES | COc1cccc2c1ncc1c2n(C2CCCC2)c(=O)n(-c2cc(C)cs2)c1=O |
Structure |
|