Ki Summary

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Target

Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)

Ligand

BDBM135819

Substrate/Competitor

n/a

Meas. Tech.

TR-FRET-Based Assay

Temperature

303.15±n/a K

IC50

55±n/a nM

Comments

extracted

Citation

Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016

More Info.:

Get all data from this article, Assay Method

Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)

Name:

Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10)

Synonyms:

DPDE3 | PDE4D | PDE4D_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) | phosphodiesterase 4D

Type:

Enzyme

Mol. Mass.:

68570.22

Organism:

Homo sapiens (Human)

Description:

Q08499-3

Residue:

604

Sequence:

MSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINK
ATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRS
GNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFG
VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLI
TYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVD
HPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKM
VIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPT
KPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWET
WADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGE
SDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDR
SPDT

BDBM135819

n/a

Name

BDBM135819

Synonyms:

US10085990, Example 103 | US10568888, Example 103 | US8853226, 103 | US9393245, 103

Type

Small organic molecule

Emp. Form.

C25H22ClN3O5

Mol. Mass.

479.912

SMILES

COc1cccc2c1ncc1c2n(C2CC[C@@H](CC2)C(O)=O)c(=O)n(-c2cccc(Cl)c2)c1=O |r,wU:16.21,(-4.67,-5.78,;-3.33,-5,;-3.33,-3.47,;-4.67,-2.69,;-4.67,-1.15,;-3.33,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;.67,-2.69,;.67,-1.15,;-.67,-.38,;-.67,1.15,;-2,1.93,;-2,3.47,;-3.33,4.23,;-4.67,3.47,;-4.67,1.93,;-3.33,1.15,;-6,4.23,;-7.34,3.47,;-6,5.78,;.67,1.93,;.67,3.47,;2,1.15,;3.33,1.93,;3.33,3.47,;4.67,4.23,;6,3.47,;6,1.93,;7.34,1.15,;4.67,1.15,;2,-.38,;3.33,-1.15,)|

Structure