| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) |
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| Ligand | BDBM135822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET-Based Assay |
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| Temperature | 303.15±n/a K |
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| IC50 | 59±n/a nM |
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| Comments | extracted |
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| Citation |  Mjalli, AM; Gaddam, B; Polisetti, DR; Kostura, MJ; Guzel, M Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors US Patent US9393245 Publication Date 7/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) |
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| Name: | Isoform 10 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) |
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| Synonyms: | DPDE3 | PDE4D | PDE4D_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (10) | phosphodiesterase 4D |
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| Type: | Enzyme |
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| Mol. Mass.: | 68570.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08499-3 |
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| Residue: | 604 |
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| Sequence: | MSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNFAALTNLQDRAPSKRSPMCNQPSINK
ATITEEAYQKLASETLEELDWCLDQLETLQTRHSVSEMASNKFKRMLNRELTHLSEMSRS
GNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISGVKKLMHSSSLTNSSIPRFG
VKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLI
TYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVD
HPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKM
VIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPT
KPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWET
WADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEGRQGQTEKFQFELTLEEDGE
SDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDR
SPDT
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| BDBM135822 |
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| n/a |
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| Name | BDBM135822 |
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| Synonyms: | US10085990, Example 121 | US10568888, Example 121 | US8853226, 121 | US9393245, 121 | US9833457, 121 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25ClN4O5S |
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| Mol. Mass. | 529.008 |
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| SMILES | CCS(=O)(=O)N1CCC(CC1)n1c2c3cccc(OC)c3ncc2c(=O)n(-c2cccc(Cl)c2)c1=O |
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| Structure | 
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