| Reaction Details |
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 | Report a problem with these data |
| Target | Seed linoleate 13S-lipoxygenase-1 |
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| Ligand | BDBM4375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro LOX Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 6.00e+5±n/a nM |
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| Comments | extracted |
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| Citation |  Litinas, KE; Mangos, A; Nikkou, TE; Hadjipavlou-Litina, DJ Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers. J Enzyme Inhib Med Chem26:805-12 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Seed linoleate 13S-lipoxygenase-1 |
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| Name: | Seed linoleate 13S-lipoxygenase-1 |
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| Synonyms: | 15-LOX | 15-Lipo-oxygenase (15-LO) | 15-lipo-oxygenase (SLO) | Arachidonic Acid 15- Lipoxygenase | L-1 | LOX1 | LOX1.1 | LOX1_SOYBN | Lipoxygenase (LOX) | Lipoxygenase (SLO) | Lipoxygenase-1 | Seed lipoxygenase-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 94365.66 |
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| Organism: | Glycine max (soybean) |
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| Description: | n/a |
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| Residue: | 839 |
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| Sequence: | MFSAGHKIKGTVVLMPKNELEVNPDGSAVDNLNAFLGRSVSLQLISATKADAHGKGKVGK
DTFLEGINTSLPTLGAGESAFNIHFEWDGSMGIPGAFYIKNYMQVEFFLKSLTLEAISNQ
GTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAPLVSYREEELKSLRGNGTGERKEY
DRIYDYDVYNDLGNPDKSEKLARPVLGGSSTFPYPRRGRTGRGPTVTDPNTEKQGEVFYV
PRDENLGHLKSKDALEIGTKSLSQIVQPAFESAFDLKSTPIEFHSFQDVHDLYEGGIKLP
RDVISTIIPLPVIKELYRTDGQHILKFPQPHVVQVSQSAWMTDEEFAREMIAGVNPCVIR
GLEEFPPKSNLDPAIYGDQSSKITADSLDLDGYTMDEALGSRRLFMLDYHDIFMPYVRQI
NQLNSAKTYATRTILFLREDGTLKPVAIELSLPHSAGDLSAAVSQVVLPAKEGVESTIWL
LAKAYVIVNDSCYHQLMSHWLNTHAAMEPFVIATHRHLSVLHPIYKLLTPHYRNNMNINA
LARQSLINANGIIETTFLPSKYSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSTPHG
VRLLIEDYPYAADGLEIWAAIKTWVQEYVPLYYARDDDVKNDSELQHWWKEAVEKGHGDL
KDKPWWPKLQTLEDLVEVCLIIIWIASALHAAVNFGQYPYGGLIMNRPTASRRLLPEKGT
PEYEEMINNHEKAYLRTITSKLPTLISLSVIEILSTHASDEVYLGQRDNPHWTSDSKALQ
AFQKFGNKLKEIEEKLVRRNNDPSLQGNRLGPVQLPYTLLYPSSEEGLTFRGIPNSISI
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| BDBM4375 |
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| n/a |
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| Name | BDBM4375 |
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| Synonyms: | (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid (9) | 3,4-Dihydroxycinnamate, XVII | CHEMBL145 | Caffeic acid | Caffeic acid, 1 | cid_689043 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H8O4 |
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| Mol. Mass. | 180.1574 |
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| SMILES | OC(=O)\C=C\c1ccc(O)c(O)c1 |
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| Structure | 
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