Reaction Details | |||
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Target | Glycogen synthase kinase-3 beta | ||
Ligand | BDBM235826 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Inhibition Assay | ||
IC50 | 3238±n/a nM | ||
Citation | Dannhardt, G; Plutizki, S; Kramb, J; Müller, A; Möhler, M 3-(indolyl)- or 3-(azaindolyl)- 4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma US Patent US9364459 Publication Date 6/14/2016 | ||
More Info.: | Get all data from this article, Assay Method | ||
Glycogen synthase kinase-3 beta | |||
Name: | Glycogen synthase kinase-3 beta | ||
Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B | ||
Type: | Enzyme | ||
Mol. Mass.: | 46756.38 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49841 | ||
Residue: | 420 | ||
Sequence: |
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BDBM235826 | |||
n/a | |||
Name | BDBM235826 | ||
Synonyms: | US9364459, N | ||
Type | Small organic molecule | ||
Emp. Form. | C29H36N4O5 | ||
Mol. Mass. | 520.6188 | ||
SMILES | COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH+]2CC[NH+](C)CC2)c2ccccc12 |t:13,(1.93,-1.66,;3.42,-1.27,;3.82,.22,;2.73,1.31,;3.13,2.8,;4.61,3.2,;5.7,2.11,;7.19,2.51,;7.59,3.99,;5.3,.62,;6.39,-.47,;7.88,-.07,;2.36,4.13,;.82,4.13,;.34,5.6,;-.99,6.37,;1.59,6.5,;2.83,5.6,;4.17,6.37,;.05,2.8,;.52,1.33,;-.72,.43,;-.72,-1.11,;-2.06,-1.88,;-2.06,-3.42,;-3.39,-4.19,;-4.73,-3.42,;-6.06,-4.19,;-6.06,-5.73,;-7.88,-6.5,;-4.73,-6.5,;-3.39,-5.73,;-1.97,1.33,;-3.48,1.01,;-4.51,2.16,;-4.03,3.62,;-2.52,3.94,;-1.49,2.8,)| | ||
Structure |