| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit alpha-4 |
|---|
| Ligand | BDBM235903 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | [35S]-TBPS Displacement Assay |
|---|
| IC50 | 1330±450 nM |
|---|
| Citation |  Covey, D Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for GABA type-A receptors US Patent US9365502 Publication Date 6/14/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Gamma-aminobutyric acid receptor subunit alpha-4 |
|---|
| Name: | Gamma-aminobutyric acid receptor subunit alpha-4 |
|---|
| Synonyms: | GBRA4_RAT | Gabra4 | Gamma-aminobutyric acid receptor (GABA(A)) subunit alpha-4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60972.37 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P28471 |
|---|
| Residue: | 552 |
|---|
| Sequence: | MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYD
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPP
EVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESS
ETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGAR
LGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYL
SKDTMEKSESLM
|
|
|
|---|
| BDBM235903 |
|---|
| n/a |
|---|
| Name | BDBM235903 |
|---|
| Synonyms: | US9365502, MQ-47 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H28O2 |
|---|
| Mol. Mass. | 276.4137 |
|---|
| SMILES | C[C@@]12CC3CC[C@H]4C[C@H](O)CCC4C3CC1CCC2=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
