| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM25902 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CA Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 2.61e+5±n/a nM |
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| Comments | extracted |
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| Citation |  Liu, F; Martin-Mingot, A; Lecornué, F; Jouannetaud, MP; Maresca, A; Thibaudeau, S; Supuran, CT Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry. J Enzyme Inhib Med Chem27:886-91 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM25902 |
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| n/a |
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| Name | BDBM25902 |
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| Synonyms: | 4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbenzoic acid | CHEMBL35 | Frusemide | Furanthril | Furosemide | Furosemide (3) | Furosemide, 4 | Lasix | US10172837, Furosemide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H11ClN2O5S |
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| Mol. Mass. | 330.744 |
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| SMILES | NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl |
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| Structure | 
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