| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
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| Ligand | BDBM238192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization-Based Binding Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 490±150 nM |
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| IC50 | 2540±780 nM |
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| Comments | extracted |
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| Citation |  Nikolovska-Coleska, Z; Abulwerdi, F; Showalter, H; Miao, L; Stuckey, J; Mady, A Small molecule inhibitors of MCL-1 and uses thereof US Patent US9394303 Publication Date 7/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog |
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| Synonyms: | Bcl-2-related protein EAT/mcl1 | MCL1_MOUSE | Mcl-1 | Mcl1 |
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| Type: | Developmental protein |
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| Mol. Mass.: | 35215.08 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 331 |
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| Sequence: | MFGLRRNAVIGLNLYCGGASLGAGGGSPAGARLVAEEAKARREGGGEAALLPGARVVARP
PPVGAEDPDVTASAERRLHKSPGLLAVPPEEMAASAAAAIVSPEEELDGCEPEAIGKRPA
VLPLLERVSEAAKSSGADGSLPSTPPPPEEEEDDLYRQSLEIISRYLREQATGSKDSKPL
GEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVT
NWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFF
HVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM238192 |
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| n/a |
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| Name | BDBM238192 |
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| Synonyms: | US9394303, 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25N3O3 |
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| Mol. Mass. | 463.5271 |
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| SMILES | Cc1nn(Cc2ccc(Oc3ccccc3)cc2)c2nc(CCc3ccccc3)cc(C(O)=O)c12 |
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| Structure | 
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