| Reaction Details |
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 | Report a problem with these data |
| Target | Lysosomal acid glucosylceramidase |
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| Ligand | BDBM238215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 4.5±n/a |
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| Ki | 18630±1650 nM |
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| IC50 | 44960±3990 nM |
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| Comments | extracted |
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| Citation |  Wustman, BA Method for the treatment of neurological disorders by enhancing the activity of β-glucocerebrosidase US Patent US9402837 Publication Date 8/2/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysosomal acid glucosylceramidase |
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| Name: | Lysosomal acid glucosylceramidase |
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| Synonyms: | Acid beta-glucosidase | Alglucerase | Beta-glucocerebrosidase | Beta-glucocerebrosidase (GC) | D-glucosyl-N-acylsphingosine glucohydrolase | GBA | GBA1 | GBA1_HUMAN | GC | GCase | GLUC | Glucocerebrosidase (GBA) | Glucosylceramidase (GBA) | Glucosylceramidase (GCase) | Glucosylceramidase precursor (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase) | Imiglucerase | beta-glucocerebrosidase (GCase) |
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| Type: | Enzyme |
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| Mol. Mass.: | 59724.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The beta-Glu activity was measured with commercially available beta-glucocerebrosidase (Ceredase) as the enzyme source. |
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| Residue: | 536 |
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| Sequence: | MEFSSPSREECPKPLSRVSIMAGSLTGLLLLQAVSWASGARPCIPKSFGYSSVVCVCNAT
YCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGF
GGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDD
FQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQP
GDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIA
RDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAK
ATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDW
NLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQK
NDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQ
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| BDBM238215 |
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| n/a |
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| Name | BDBM238215 |
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| Synonyms: | US9402837, 25 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H18N2O5 |
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| Mol. Mass. | 282.2924 |
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| SMILES | OC[C@H]1CN(Cc2ccc(cc2)[N+]([O-])=O)C[C@@H](O)[C@@H]1O |
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| Structure | 
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