Reaction Details |
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Target | Tyrosyl-DNA phosphodiesterase 1 |
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Ligand | BDBM50425044 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Gel-based Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 15000±3000 nM |
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Comments | extracted |
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Citation | Cushman, MS; Nguyen, TX; Conda-Sheridan, MM; Pommier, YG Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors US Patent US9402842 Publication Date 8/2/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosyl-DNA phosphodiesterase 1 |
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Name: | Tyrosyl-DNA phosphodiesterase 1 |
Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
Type: | Enzyme |
Mol. Mass.: | 68430.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9NUW8 |
Residue: | 608 |
Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
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BDBM50425044 |
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n/a |
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Name | BDBM50425044 |
Synonyms: | CHEMBL2312899 | US9402842, 51 |
Type | Small organic molecule |
Emp. Form. | C20H17N3O5 |
Mol. Mass. | 379.3661 |
SMILES | COc1ccc2C(=O)c3c(-c2c1)n(CCCN)c(=O)c1cc(ccc31)[N+]([O-])=O |
Structure |
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