| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-2 |
|---|
| Ligand | BDBM238637 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Homogeneous Time Resolved Fluorescence Assay (HTRF) |
|---|
| pH | 7±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 0.109±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Cee, V; Chavez, Jr., F; Chen, JJ; Harrington, EH; Herberich, B; Jackson, CL; Lanman, BA; Nguyen, TT; Norman, MH; Pettus, LH; Reed, AB; Smith, AL; Tamayo, NA; Tasker, A; Wang, H; Wu, B; Wurz, R Amides as pim inhibitors US Patent US9394297 Publication Date 7/19/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase pim-2 |
|---|
| Name: | Serine/threonine-protein kinase pim-2 |
|---|
| Synonyms: | PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2) |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 34185.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9P1W9 |
|---|
| Residue: | 311 |
|---|
| Sequence: | MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
|
|
|
|---|
| BDBM238637 |
|---|
| n/a |
|---|
| Name | BDBM238637 |
|---|
| Synonyms: | US9394297, 297 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22FN5O |
|---|
| Mol. Mass. | 367.42 |
|---|
| SMILES | C[C@H]1NC(=O)c2cc([nH]c12)-c1c(F)ccc2nc(C)c(NC(C)(C)C)nc12 |
|---|
| Structure | 
|
|---|
Search and Browse
