Reaction Details |
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Target | Orexin receptor type 2 |
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Ligand | BDBM240210 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Intracellular Calcium Assay |
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Temperature | 310.15±n/a K |
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IC50 | 5±n/a nM |
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Comments | extracted |
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Citation | Bolli, M; Boss, C; Brotschi, C; Heidmann, B; Sifferlen, T; Williams, JT Azetidine amide derivatives as orexin receptor antagonists US Patent US9403813 Publication Date 8/2/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Orexin receptor type 2 |
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Name: | Orexin receptor type 2 |
Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
Type: | Protein |
Mol. Mass.: | 50710.53 |
Organism: | Homo sapiens (Human) |
Description: | O43614 |
Residue: | 444 |
Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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BDBM240210 |
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n/a |
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Name | BDBM240210 |
Synonyms: | US9403813, 116 |
Type | Small organic molecule |
Emp. Form. | C25H22ClN5O3 |
Mol. Mass. | 475.927 |
SMILES | COc1cc(C(=O)N2CC[C@H]2c2noc(n2)-c2cccc(Cl)c2C)c(cc1C)-c1ncccn1 |
Structure |
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