| Reaction Details |
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 | Report a problem with these data |
| Target | Fatty acid synthase |
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| Ligand | BDBM50242188 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FAS Inhibitory Assay |
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| pH | 7±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 1.71e+4± 1.5e+3 nM |
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| Citation |  Oh, J; Hwang, IH; Hong, CE; Lyu, SY; Na, M Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity. J Enzyme Inhib Med Chem28:565-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fatty acid synthase |
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| Name: | Fatty acid synthase |
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| Synonyms: | FAS | FASN | FAS_CHICK | Fatty acid synthase (FAS) |
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| Type: | Enzyme |
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| Mol. Mass.: | 274770.36 |
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| Organism: | Gallus gallus (Chicken) |
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| Description: | P12276 |
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| Residue: | 2512 |
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| Sequence: | MEDVVIAGIAGKLPESENLQEFWENLLNGVDMVTEDDRRWKPGIYGLPKRNGKLKDIKKF
DASFFGVHPKQAHTMDPQLRLLLEVSYEAILDGGINPTALRGTDTGVWVGASGSEALEAL
SQDPEELLGYSMTGCQRAMLANRISYFYDFTGPSLTIDTACSSSLMALENAYKAIRHGQC
SAALVGGVNILLKPNTSVQFMKLGMLSPDGACKAFDVSGNGYCRSEAVVVVLLTKKSMAK
RVYATIVNAGSNTDGFKEQGVTFPSGEMQQQLVGSLYRECGIKPGDVEYVEAHGTGTKVG
DPQEVNGIVNVFCQCEREPLLIGSTKSNMGHPEPASGLAALAKVILSLEHGLWAPNLHFN
DPNPDIPALHDGSLKVVCKPTPVKGGLVSINSFGFGGSNAHVILRPNEKKCQPQETCNLP
RLVQVCGRTQEAVEILIEESRKHGGCSPFLSLLSDISAVPVSSMPYRGYTLVGTESDITE
IQQVQASGRPLWYICSGMGTQWKGMGLSLMKLDLFRQSILRSDEALKSTGLKVSDLLLNA
DENTFDDTVHAFVGLAAIQIAQIDVLKAAGLQPDGILGHSVGELACGYADNSLSHEEAVL
AAYWRGRCVKEAKLPPGGMAAVGLTWEECKQRCPPNVVPACHNSEDTVTVSGPLDSVSEF
VTKLKKDGVFAKEVRRAGVAFHSYYMASIAPALLSALKKVIPHPKPRSARWISTSIPESQ
WQSDLARNSSAEYHVNNLVNPVLFHEGLKHIPENAVVVEIAPHALLQAILRRTLKPTCTI
LPLMKKDHKNNLEFFLTQTGKIHLTGINVLGNNLFPPVEYPVPVGTPLISPYIKWDHSQD
WDVPKAEDFPSGSKGSASASVYNIDVSPDSPDHYLVGHCIDGRVLYPATGYLVLAWRTLA
RSLGMVMEQTAVMFEEVTIHQATILPKKGSTQLEVRIMPASHSFEVSGNGNLAVSGKISL
LENDALKNFHNQLADFQSQANVTAKSGLLMEDVYQELHLRGYNYGPTFQGVLECNSEGSA
GKILWNGNWVTFLDTLLHLIVLAETGRSLRLPTRIRSVYIDPVLHQEQVYQYQDNVEAFD
VVVDRCLDSLKAGGVQINGLHASVAPRRQQERISPTLEKFSFVPYIESDCLSSSTQLHAY
LEHCKGLIQKLQAKMALHGVKLVIHGLETKGAAAGSPPAQKGLQHILTEICRLELNGNPH
SELEQIVTQEKMHLQDDPLLNGLLDSSELKTCLDVAKENTTSHRMKIVEALAGSGRLFSR
VQSILNTQPLLQLDYIATDCTPETLSDNETELHDAGISFSQWDPSSLPSGNLTNADLAVC
NCSTSVLGNTAEIISNLAAAVKEGGFVLLHTLLKEETLGEIVSFLTSPDLQQKHSFLSQA
QWEELFSKASLNLVAMKRSFFGSVIFLCRRQSPAKAPILLPVDDTHYKWVDSLKEILADS
SEQPLWLTATNCGNSGILGMVNCLRLEAEGHRIRCVFVSNLSPSSTVPATSLSSLEMQKI
IERDLVMNVYRDGKWGSFRHLPLQQAQPQELTECAYVNVLTRGDLSSLRWIVSPLRHFQT
TNPNVQLCKVYYASLNFWDIMLATGKLSPDAIPGNWTLQQCMLGMEFSGRDLAGRRVMGL
LPAKGLATVVDCDKRFLWEVPENWTLEEAASVPVVYATAYYALVVRGGMKKGESVLIHSG
SGGVGQAAIAIALSMGCRVFATVGSAEKREYLQARFPQLDANSFASSRNTTFQQHILRVT
NGKGVSLVLNSLAEEKLQASLRCLAQHGRFLEIGKFDLSNNSQLGMALFLKNVAFHGILL
DSIFEEGNQEWEVVSELLTKGIKDGVVKPLRTTVFGKEEVEAAFRFMAQGKHIGKVMIKI
QEEEKQYPLRSEPVKLSAISRTSCPPTKSYIITGGLGGFGLELAQWLIERGAQKLVLTSR
SGIRTGYQAKCVREWKALGIQVLVSTSDVGTLEGTQLLIEEALKLGPVGGIFNLAVVLKD
AMIENQTPELFWEVNKPKYSGTLHLDWVTRKKCPDLDYFVVFSSVSCGRGNAGQSNYGFA
NSAMERICEQRHHDGLPGLAVQWGAIGDVGILKAMGNREVVIGGTVLQQISSCLEVLDMF
LNQPHPVMSSFVLAEKVSVKSEGGSQRDLVEAVAHILGVRDVSSLNAESSLADLGLDSLM
GVEVRQTLERDYDIVMTMREIRLLTINKLRELSSKTGTAEELKPSQVLKTGPGEPPKLDL
NNLLVNPEGPTITRLNEVQSTERPLFLVHPIEGSIAVFYTLASKLHMPCYGLQCTKAAPL
DSIQSLASYYIDCMKQIQPEGPYRIAGYSFGACVAFEMCSQLQAQQNASHALNSLFLFDG
SHSFVAAYTQSYRAKLTQGNEAALETEALCAFVQQFTGIEYNKLLEILLPLEDLEARVNA
AADLITQIHKNINREALSFAAASFYHKLKAADKYIPESKYHGNVTLMRAKTHNEYEEGLG
GDYRLSEVCDGKVSVHIIEGDHRTLLEGDGVESIIGIIHGSLAEPRVSVREG
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| BDBM50242188 |
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| n/a |
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| Name | BDBM50242188 |
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| Synonyms: | 6-(8'Z-pentadecenyl)-salicylicacid | 6-[8'(Z)-pentadecenyl]salicylic acid | 6-[8(Z)-pentadecatrienyl]salicylic acid | 6-{8(Z)-pentadecenyl}salicylic acid | 6[8'(Z )-pentadecenyl]salicylic acid | Anacardic acid 8'Z-monoene | CHEMBL445177 | Ginkgolic acid C15:1 (1) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H34O3 |
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| Mol. Mass. | 346.5036 |
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| SMILES | CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O |
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| Structure | 
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