| Reaction Details |
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 | Report a problem with these data |
| Target | Genome polyprotein [2420-3010] |
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| Ligand | BDBM240838 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HCV Replicon Assay |
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| pH | 7.5±n/a |
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| Temperature | 300.15±n/a K |
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| EC50 | >100000±n/a nM |
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| Comments | extracted |
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| Citation |  Du, J; Sofia, MJ 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections US Patent US9394331 Publication Date 7/19/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Genome polyprotein [2420-3010] |
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| Name: | Genome polyprotein [2420-3010] |
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| Synonyms: | POLG_HCVCO | RNA polymerase (NS5B) | RNA-directed RNA polymerase (NS5B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 65783.36 |
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| Organism: | Hepatitis C virus genotype 1b (isolate Con1) (HCV) |
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| Description: | aa 2420-3010 |
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| Residue: | 591 |
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| Sequence: | SMSYTWTGALITPCAAEETKLPINALSNSLLRHHNLVYATTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIR
SVWKDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTVTENDIRVEESIY
QCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAA
AACRAAKLQDCTMLVCGDDLVVICESAGTQEDEASLRAFTEAMTRYSAPPGDPPKPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVRTKLKLTPIP
AASQLDLSSWFVAGYSGGDIYHSLSRARPRWFMWCLLLLSVGVGIYLLPNR
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| BDBM240838 |
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| n/a |
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| Name | BDBM240838 |
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| Synonyms: | US9394331, 135 | US9394331, 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H16N2O6 |
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| Mol. Mass. | 284.2652 |
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| SMILES | OCC1OC(n2ccc(=O)[nH]c2=O)[C@]2(CCCO2)[C@@H]1O |r| |
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| Structure | 
|
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